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Q&A with Dr. J: The Top 5 Genes Everyone Should Know 

 October 7, 2025

Think all genes are created equal?
Dr. J reveals the top 5 genetic variants that have the biggest impact on your daily life — from mood swings to energy crashes to immune function.

The Top 5 Genes Explained:

MAO (The Warrior Gene) – Why too much serotonin causes anxiety, irritability, and even criminal behavior
COMT – The adrenaline bottleneck that creates hypervigilance, insomnia, and PTSD susceptibility
VDR (Vitamin D Receptor) – How a broken receptor prevents neurotransmitter production and immune function
NDUFUS – The metabolism gatekeeper that controls whether you make energy from food
MTHFR – The methylation master gene affecting detox, pregnancy, and DNA repair

Critical Insight:

These genes don't work alone. Dr. J explains why taking methylfolate for MTHFR without understanding your MAO or COMT genes could make things worse. It's the interplay that matters.

Perfect for you if:

• SSRIs made you feel worse instead of better
• You can't shut your brain off at night
• Standard vitamin D supplementation hasn't helped
• You're exhausted despite eating well
• You want to understand why you are the way you are

Your body isn't broken — it's just unique. Understanding these five genes gives you the power to work with your genetics instead of against them.


Tags

COMT, genetics, Important Genes, MAO, MTHFR, VDR


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